Winforms ADO.NET to ASP.NET

Dear guys, can i interact with database on a web space via ftp or http from my winform application? if so then whats the starting point? Why i want to do this is becuase i have A client server application. My clients will upload data to some specific location, my server with download from the same location, will merge them and will make it interactive. Right now iam doing this with a dumb approach as i explained but i want it to be streamlined just like as smooth as desktop application like all my clients are making their database transactions directly to online database as their backend file eliminating the need to download and upload the same database file again and again!!! Right now iam using access 2010. Any advice(s) or any other better approach to do so are appreciated. Regards.

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